Bedoukian     Laser Vibrometer

Animal Taxa
Plant Taxa
Floral Compounds
Semiochemical Detail
Semiochemicals & Taxa
Invasive spp.


Email to a Friend
Kindly Donate for The Pherobase

« Previous AbstractOestrous cycle disruption in group-housed mice: evaluation of the involvement of tactile and pheromonal stimuli    Next AbstractAcute effects and exposure to organic compounds in road maintenance workers exposed to asphalt »

Acta Gastroenterol Latinoam

Title:Effect of loperamide and bisacodyl on intestinal transit time, fecal weight and short chain fatty acid excretion in the rat
Author(s):Bustos, D.Ogawa, K.Pons, S.Soriano, E.Bandi, J. C.Bustos Fernandez, L.
Address:Instituto de Gastroenterologia Dr. Jorge Perez Companc, Buenos Aires, Rep. Argentina.
Journal Title:Acta Gastroenterol Latinoam
Page Number:09-Mar
ISSN/ISBN:0300-9033 (Print). 0300-9033 (Linking)
Abstract:We analyzed the effect of drugs that modify the colonic motility on rat intestinal transit time (ITT) (measured with radiopaque markers), fecal weight (FW) and fecal concentration of short chain fatty acids (FSCFA) (assayed by gas liquid chromatography), over a four-week period. Bisacodyl was used to accelerate and Loperamide to retard the intestinal transit in rats maintained on a conventional diet. The first and 3rd week were drug-free control periods. The mean values of these periods were: ITT = 28.9h +/- 1.9 FW: 9.2 +/- 1.2 g/24 h and FSCFA = 60.6 +/- 17.9 mmol/g. After loperamide administration, we observed an increase in the mean ITT as compared to the control period (40.4 +/- 8.0h) and decrease in FW (4.8 +/- 3.6 g/24h) and in FSCFA = 32.2 +/- 5.6 mmol/g). After bisacodyl administration, we found a shorter ITT in relation to controls (24.8 +/- 2.5h), and increases in FW (27.5 +/- 3.6g/24h) and in FSCFA (108.2 +/- 39.9 mmol/g). There was a negative correlation between ITT and FW (R = 0.67 p less than 0.01) and a positive correlation between total SCFA concentration and FW (R = 0.71 p less than 0.01). The concentration of acetic, propionic and butyric acids increased with progressive increments in fecal weight, whereas concentrations of isovaleric and caproic acids decreased. The results of this study show that the FW and the FSCFA may be influenced by modifications in the intestinal transit time.

Back to top
Citation: El-Sayed AM. The Pherobase: Database of Pheromones and Semiochemicals. <>.
The Pherobase - Extensive Database of Pheromones and Semiochemicals. Ashraf M. El-Sayed.