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An Acad Bras Cienc


Title:New enamine derivatives of lapachol and biological activity
Author(s):Oliveira, M. F. Lemos, T. G. de Mattos, M. C. Segundo, T. A. Santiago, G. M. Braz-Filho, R.
Address:Departamento de Quimica Organica e Inorganica, Universidade Federal do Ceara, Fortaleza, Ceara, Brazil.
Year:2002 Jun
Journal Title:An Acad Bras Cienc
Page Number:211-21
Language:eng
Volume:74
Issue:2
ISSN/ISBN:0001-3765 (Print). 0001-3765 (Linking)
 
Abstract:A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells.
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Citation: El-Sayed AM. The Pherobase: Database of Pheromones and Semiochemicals. <http://www.pherobase.com>.
The Pherobase - Extensive Database of Pheromones and Semiochemicals. Ashraf M. El-Sayed.