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Acta Otolaryngol


Title:Overexpression of thymic stromal lymphopoietin in allergic rhinitis
Author(s):Mou, Z. Xia, J. Tan, Y. Wang, X. Zhang, Y. Zhou, B. Li, H. Han, D.
Address:Department of Otolaryngology, Hainan Provincial People's Hospital, HaiKou, China.
Year:2009 Mar
Journal Title:Acta Otolaryngol
Page Number:297-301
Language:eng
Volume:129
Issue:3
ISSN/ISBN:1651-2251 (Electronic)
 
Abstract:CONCLUSION: Thymic stromal lymphopoietin (TSLP) played an important role in the pathogenesis of allergic rhinitis (AR) and can be regarded a potential therapeutic target for the management of AR. OBJECTIVE: To evaluate the possible role of TSLP in the pathogenesis of AR. PATIENTS AND METHODS: We enrolled 16 patients of AR to investigate the expression of TSLP in nasal mucosa and evaluate the link of TSLP and interleukin-4 (IL-4). Expression of TSLP was detected by immunohistochemical analysis and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), and concentrations of TSLP and IL-4 were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: TSLP was detected in all samples and the mRNA and protein expression of TSLP is increased significantly in AR nasal mucosa compared with normal control (P<0.05). TSLP production is tightly correlated with IL-4 and severity of AR (P<0.05).
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Citation: El-Sayed AM. The Pherobase: Database of Pheromones and Semiochemicals. <http://www.pherobase.com>.
The Pherobase - Extensive Database of Pheromones and Semiochemicals. Ashraf M. El-Sayed.