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Am J Epidemiol


Title:Molecular sequence data of hepatitis B virus and genetic diversity after vaccination
Author(s):van Ballegooijen, W. M. van Houdt, R. Bruisten, S. M. Boot, H. J. Coutinho, R. A. Wallinga, J.
Address:RIVM, National Institute for Public Health and the Environment, Bilthoven, The Netherlands. marijn.van.ballegooijen@rivm.nl
Year:2009 Dec 15
Journal Title:Am J Epidemiol
Page Number:1455-63
Language:eng
Volume:170
Issue:12
ISSN/ISBN:1476-6256 (Electronic). 0002-9262 (Linking)
 
Abstract:The effect of vaccination programs on transmission of infectious disease is usually assessed by monitoring programs that rely on notifications of symptomatic illness. For monitoring of infectious diseases with a high proportion of asymptomatic cases or a low reporting rate, molecular sequence data combined with modern coalescent-based techniques offer a complementary tool to assess transmission. Here, the authors investigate the added value of using viral sequence data to monitor a vaccination program that was started in 1998 and was targeted against hepatitis B virus in men who have sex with men in Amsterdam, the Netherlands. The incidence in this target group, as estimated from the notifications of acute infections with hepatitis B virus, was low; therefore, there was insufficient power to show a significant change in incidence. In contrast, the genetic diversity, as estimated from the viral sequence collected from the target group, revealed a marked decrease after vaccination was introduced. Taken together, the findings suggest that introduction of vaccination coincided with a change in the target group toward behavior with a higher risk of infection. The authors argue that molecular sequence data provide a powerful additional monitoring instrument, next to conventional case registration, for assessing the impact of vaccination.
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Citation: El-Sayed AM. The Pherobase: Database of Pheromones and Semiochemicals. <http://www.pherobase.com>.
The Pherobase - Extensive Database of Pheromones and Semiochemicals. Ashraf M. El-Sayed.