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Compound - 2R5S-pityol [(2R,5S)-2-(1-Hydroxy-1-methylethyl)-5-methyltetrahydrofuran]

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(2R,5S)-2-(1-Hydroxy-1-methylethyl)-5-methyltetrahydrofuran Formula:  C8H16O2  CAS#:  3284-88-6  MW:  144.21  [MS]  [ NMR ]  [Behavioural function]

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Reference(s) for synthesis of (2R,5S)-2-(1-Hydroxy-1-methylethyl)-5-methyltetrahydrofuran [2R5S-pityol] Ishihara, K., Mori, A., and Yamamoto, H. 1987. Stereoselective reduction of bicyclic acetals. A method for reductive generation of heterocyclic ring systems. Tetrahedron Lett. 28:6613-6616.   Ishihara, K., Mori, A., and Yamamoto, H. 1990. Stereoselective reduction of acetals. A method for reductive generation of heterocyclic ring systems. Tetrahedron. 46:4595-4612.   Kennedy, R.M., and Tang, S. 1992. Directed oxidative cyclization of 5-hydroxyalkenes with rhenium oxide. Tetrahedron Lett. 33:3729-3731.   Lattanzi, A., Sala, G.D., Russo, M., and Scettri, A. 2001. Diastereoselective titanocene-catalyzed oxidative cyclization of bishomoallylic alcohols. Syn. Lett. 9:1479-1481.   Steinreiber, A., Edegger, K., Mayer, S.F., and Faber, K. 2001. Enantio- and diastereo-convergent synthesis of (2R,5R)- and (2R,5S)-Pityol through enzyme-triggered ring closure. Tetrahedron: Asymmetry. 12:2067-2071.   Tang, S., and Kennedy, R.M. 1992. Stereocontrolled oxidation of 5-hydroxyalkenes with rhenium oxide. Tetrahedron Lett. 33:5299-5302.